Mac Jones reconnects with Kendrick Bourne as Brock Purdy misses time, placing Bourne in a crucial Week 2 role for the 49ers and tightening the swing from Jones to SF’s new-season targets. The Saints’ Week 1 jitters and a mobile Spencer Rattler complicate SF’s game plan, but Bourne’s familiar chemistry could yield a clean, high-floor target in a tough road matchup.

New Orleans showed a rough debut under Moore, piling up penalties while leaning on Kamara and Miller in the run game. SF’s defense must contend with Rattler’s movement and Saints’ ground game, setting up SF to capitalize if the breakdowns linger and Bourne delivers as a reliable outlet in Jones’s limited-but-possible Week 2 volume.

Week 2 fantasy decisions center on high-profile wideouts and how injuries, matchups, and QB play shape ceilings. Pittman Jr. may see fewer targets against Denver’s Patrick Surtain II despite practicing; Waddle’s shoulder adds risk against New England if he suits up, while Jameson Williams could benefit from a softer Week 2 matchup with Chicago. Rome Odunze emerged as Caleb Williams’ favorite target early, Marvin Harrison Jr. faces Jaycee Horn’s shadow in a tough Week 2 tilt, and Olave, DeVonta Smith, Diggs, Zay Flowers, and Jeudy are all in the crosshairs of tough lineup calls. The Who Should I Start tool remains the quick path to a confidence-booster, letting you compare up to four players with format-aware projections and up-to-date news.

In short, Week 2 starts hinge on health plus matchup nuance: Lions WRs versus Detroit’s pass-friendly defense, Panthers’ cornerback matchups for Harrison Jr., and the ever-present WR1/WR2 balance in Philadelphia and Buffalo. The piece also highlights the tool’s improvements—tiles, bye-week awareness, and scoring-format options—so fantasy managers can build stronger, data-driven lineups in real time.